Anti-MMAF (Monomethyl Auristain F) antibody, mAb

Background

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. MMAF is an antitubulin agent that inhibits

cell division by blocking the polymerization of tubulin. Because of MMAF is highly toxic, it cannot be used as a

drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a

monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal

antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell,

thus activating the anti-mitotic mechanism.

Immunogen: MMAF-KLH

Specificity: Specifically recognizes the target-Monomethyl Auristain F (MMAF)

Source: Mouse, Monoclonal Clone #05

Isotype: IgG1

Conjugate: Unconjugated

Concentration: 1.0 mg/ml

Purity: > 90% as determined by SDS-PAGE

Tested applications: ELISA

Recommended dilution: 1:1,000 - 1:5,000 (optimal dilutions should be determined by the end use.)

Storage Buffer: PBS Buffer, pH7.4

Storage: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Stable for 2

years from date of receipt. Aliquot to avoid repeated freezing and thawing.

* Please note: FOR RESEARCH USE ONLY