Anti- DM1 antibody, mAb

Background

Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to

overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine is a

strong antiproliferative chemotherapeutics toward over 60 types of cancer cell lines. Mertansine (0-1 μg/mL)

shows antitumor activity in malignant B16F10 melanoma cells, and inhibits tumor cell growth by inhibiting

mitosis when combined with DTX Mertansine can be attached to a monoclonal antibody with a linker to create an

antibody-drug conjugate (ADC).

Immunogen: DM1-KLH

Specificity: Specifically recognizes the target-DM1（Mertansine）

Source: Mouse, Monoclonal Clone #01

Isotype: IgG2b

Conjugate: Unconjugated

Concentration: 1.0mg/ml

Purity: > 90% as determined by SDS-PAGE

Tested applications: ELISA

Recommended dilution: 1:1,000 - 1:5,000 (optimal dilutions should be determined by the end use.)

Storage Buffer: PBS Buffer, pH7.4

Storage: Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Stable for 2

years from date of receipt. Aliquot to avoid repeated freezing and thawing.

* Please note: FOR RESEARCH USE ONLY